Thalidomide-type teratogenicity: structure–activity relationships for congeners
نویسندگان
چکیده
منابع مشابه
Nitric oxide rescues thalidomide mediated teratogenicity
Thalidomide, a sedative drug given to pregnant women, unfortunately caused limb deformities in thousands of babies. Recently the drug was revived because of its therapeutic potential; however the search is still ongoing for an antidote against thalidomide induced limb deformities. In the current study we found that nitric oxide (NO) rescues thalidomide affected chick (Gallus gallus) and zebrafi...
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The intercalation of thalidomide (alpha-phthalimidoglutarimide) into nucleic acids was studied by spectrophotometric titrations, displacement of known intercalators, viscosity changes of DNA solutions, and by phase partition analysis. Specific binding of thalidomide was found to DNA of various specimens (human placenta, calf thymus, salmon sperm), but not to RNA (from bakers yeast, torula yeast).
متن کاملIdentification of a primary target of thalidomide teratogenicity.
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today, thalidomide is still used in the treatment of leprosy and multiple myeloma, although how it causes limb malformation and other developmental defects is unknown. Here, we identified cereblon (CRBN) as a thalidomide-binding protein. CRBN for...
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نامساوی کوشی-شوارتز در حالت کلاسیک در فضای اندازه فازی برقرار نمی باشد اما با اعمال شرط هایی در مسئله مانند یکنوا بودن توابع و قرار گرفتن در بازه صفر ویک می توان دو نوع نامساوی کوشی-شوارتز را در فضای اندازه فازی اثبات نمود.
15 صفحه اولRediscovering Thalidomide
Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders thought to have an autoimmune or inflammatory basis. A review of the literature focused on clini...
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ژورنال
عنوان ژورنال: Toxicology Research
سال: 2018
ISSN: 2045-4538
DOI: 10.1039/c8tx00187a